カサシマ　ヨシオ   YOSHIO KASASHIMA   笠嶋　義夫    所属   千葉工業大学  創造工学部 教育センター（創造工学部）    職種   教授
言語種別	日本語
発行・発表の年月	2021/12/28
形態種別	学術雑誌
査読	査読あり
標題	Attrition-Enhanced Asymmetric Transformation of Axially Chiral Nicotinamides by Dynamic Chiral Salt Formation
執筆形態	共著
掲載誌名	ChemPlusChem
掲載区分	国外
出版社・発行元	Wiley-VCH GmbH
巻・号・頁	87(1),e202100504頁
総ページ数	7
著者・共著者	Takumi Nakamura, Hiroki Ishikawa, Kazuma Ban, Yasushi Yoshida, Takashi Mino, Yoshio Kasashima, and Masami Sakamoto
概要	Atroposelective resolution for axially chiral nicotinamides was achieved by dynamic chiral salt formation with L-DBTA using six types of nicotinamides that could not be optically resolved by the preferential crystallization method. Kinetic studies of their racemization indicated that the chiral conformation was retained for a significant period of time. Two methods of crystallization-induced asymmetric transformation were examined by dynamic diastereomeric salt formation: solvent evaporation from a supersaturated solution, and attrition-enhanced asymmetric transformation.
DOI	doi.org/10.1002/cplu.202100504
ISSN	2192-6506