カサシマ　ヨシオ   YOSHIO KASASHIMA   笠嶋　義夫    所属   千葉工業大学  創造工学部 教育センター（創造工学部）    職種   教授
言語種別	英語
発行・発表の年月	2022/07/01
形態種別	学術雑誌
査読	査読あり
標題	Behavior of All Chiral Standard Amino Acids for Chiral Symmetry Breaking of p-Anisoin
執筆形態	共著
掲載誌名	Crystal Growth & Design
掲載区分	国外
出版社・発行元	American Chemical Society
巻・号・頁	22(8),pp.4673-4679
総ページ数	7
著者・共著者	Norika Miyazaki, Kazutaka Sanada, Takumi Nakamura, Aoi Washio, Yasushi Yoshida, Takashi Mino, Yoshio Kasashima, and Masami Sakamoto*
概要	The asymmetric amplification of p-anisoin was studied by attrition-enhanced deracemization in the presence of chiral standard amino acids. In this reaction, p-anisoin crystallized as a conglomerate, and deracemization under basic conditions was efficiently performed in 99% ee by Viedma ripening. Although the handedness of the enantioselective crystallization cannot be controlled by spontaneous crystallization, it could be governed by the coexistence of a catalytic amount of 16 chiral amino acids except cysteine, serine, and threonine. l-Amino acids tilted the handedness of enantiomer crystals to (R)-anisoin, while d-amino acids tilted it toward (S)-isomer crystals.
DOI	10.1021/acs.cgd.2c00480
ISSN	1528-7505