カサシマ ヨシオ
YOSHIO KASASHIMA
笠嶋 義夫 所属 千葉工業大学 創造工学部 教育センター(創造工学部) 職種 教授 |
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言語種別 | 英語 |
発行・発表の年月 | 2020/01/07 |
形態種別 | 学術雑誌 |
査読 | 査読あり |
標題 | Attrition-Enhanced Deracemization of Axially Chiral Nicotinamides |
執筆形態 | 共著 |
掲載誌名 | European Journal of Organic Chemistry |
掲載区分 | 国外 |
出版社・発行元 | John Wiley & Sons, Inc. |
巻・号・頁 | 2020(8),pp.1001-1005 |
総ページ数 | 5 |
著者・共著者 | Hiroki Ishikawa, Kazuma Ban, Naohiro Uemura, Yasushi Yoshida, Takashi Mino, Yoshio Kasashima, Masami Sakamoto |
概要 | Attrition-enhanced deracemization of two axially chiral nicotinamides, crystallizing as a conglomerate of a P21 crystal system, was performed. N,N-Dialkylnicotinamides with substituents on the 2- and 4-positions of the pyridine ring exhibited stable axial chirality due to rotationally restricted scaffolds for the Ar–C(=O)N bond. Crystallization of the racemic mixtures from the melt or attrition-enhanced deracemization
led to the chiral breaking of symmetry to give 95–96 % ee of enantiomorphic crystals. |
DOI | 10.1002/ejoc.201901826 |
ISSN | 1099-0690 |