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カサシマ ヨシオ
YOSHIO KASASHIMA
笠嶋 義夫 所属 千葉工業大学 創造工学部 教育センター（創造工学部） 職種 教授 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 2013/12 |
| 形態種別 | 学術雑誌 |
| 査読 | 査読あり |
| 標題 | Chiral Symmetry Breaking of Axially Chiral Nicotinamide by Crystallization from the Melt |
| 執筆形態 | 共著 |
| 掲載誌名 | Chemistry Letters |
| 出版社・発行元 | The Chemical Society of Japan |
| 巻・号・頁 | 42(12),pp.1508-1510 |
| 著者・共著者 | Fumitoshi Yagishita, Kazuma Okamoto, Norifumi Kamataki, Shota Kanno,
Takashi Mino, Yoshio Kasashima, and Masami Sakamoto |
| 概要 | One of six 2-alkylamino-4,6-dimethylnicotinamides afforded a conglomerate, and subsequent X-ray crystallographic analysis revealed that the compound crystallized in the monoclinic system, the space group P21. Crystallization of the racemic nicotinamide from the melt led to the chiral breaking of symmetry from 83 to 92% ee. This amide exhibited considerably stable axial chirality (G:22.423.5 kcal mol-1) due to rotationally restricted scaffolds for the C-C(=O) bond. |