シバタ　ミツヒロ   SHIBATA MITSUHIRO   柴田　充弘    所属   千葉工業大学  工学部 応用化学科    千葉工業大学  工学研究科 工学専攻    千葉工業大学  工学研究科 応用化学専攻    職種   教授
言語種別	英語
発行・発表の年月	2016/09
形態種別	学術雑誌
査読	査読あり
標題	Photocrosslinkable trehalose derivatives carrying mesogenic groups: Synthesis, characterization, and in vitro evaluation for fibroblast attachment
執筆形態	共著
掲載誌名	Journal of Functional Biomaterials
掲載区分	国外
出版社・発行元	MDPI
巻・号・頁	7(3),pp.24(1)-24(13)
著者・共著者	Shinya Yano, Naozumi Teramoto, Toshiaki Shimasaki and Mitsuhiro Shibata
概要	A photocrosslinkable trehalose derivative carrying mesogenic groups was synthesized by esterification reactions. The derivative (TC-HBPHA) was synthesized by the reaction of partially cinnamoyl-modified trehalose (TC4) with 4-(4-hexyloxybenzoyloxy)phenoxy-6-oxohexanoic acid (HBPHA) as a mesogenic unit. TC-HBPHA showed a nematic liquid crystalline mesophase in the heating process under observation. The dimerization of the cinnamoyl groups of TC-HBPHA by ultraviolet (UV) light irradiation was monitored by UV-Vis spectroscopy and FT-IR spectroscopy. The photocrosslinked film was obtained after the UV irradiation of TC-HBPHA,and it kept the liquid crystalline mesophase at almost the same temperature range. Fibroblast cells cultured on the photocrosslinked TC-HBPHA proliferated as well as on the polystyrene culture plate,indicating that the film has no toxicity. Interestingly, some cells on photocrosslinked TC-HBPHA had a spindle shape and aligned characteristically.