ヨシゴエ　ユウスケ   Yoshigoe Yusuke   吉越　裕介    所属   千葉工業大学  工学部 教育センター（工学部）    職種   准教授
言語種別	英語
発行・発表の年月	2021/06
形態種別	学術雑誌
査読	査読あり
標題	Regioselective C-H Trifluoromethylation of Aromatic Compounds by Inclusion in Cyclodextrins.
執筆形態	共著
掲載誌名	Organic letters
掲載区分	国外
巻・号・頁	23(11),pp.4327-4331
著者・共著者	Xu Lu, Ryohei Kawazu, Jizhou Song, Yusuke Yoshigoe, Takeru Torigoe, Yoichiro Kuninobu
概要	A regioselective radical C-H trifluoromethylation of aromatic compounds was developed using cyclodextrins (CDs) as additives. The C-H trifluoromethylation proceeded with high regioselectivity to afford the product in good yield, even on the gram scale. In the presence of CDs, some substrates underwent a single trifluoromethylation selectively, whereas mixtures of single- and double-trifluoromethylated products were formed in the absence of the CD. 1H NMR experiments indicated that the regioselectivity was controlled by the inclusion of a substrate inside the CD cavity.
DOI	10.1021/acs.orglett.1c01259
ISSN	1523-7052
PMID	33989009