Faculty Information - KUROSAKI NAOKO

Office

Academic background

Present specialized field

E-Mail Address

Research activities

Works

（Last updated : 2025-03-24 13:43:00）

KUROSAKI NAOKO
Department of Life Science, Faculty of Advanced Engineering

Graduate School of Engineering

Master's Program in Life Science, Graduate School of Advanced Engineering

Professor

■ Office

Tsudanuma Campus, No.1 Building,4th floor room 040410

■ Academic background

1992/04～1996/03

〔Doctorial Course〕, Graduate School, School of Medicine, Tokyo Medical and Dental University, Completed,

■ Present specialized field

Virology, Medical biochemistry, Hygiene and public health: including laboratory approach

■ E-Mail Address

■ Research activities

1.		Japanese Cancer Association
2.		Japanese Society for Immunology
3.		The Japanese Society for AIDS Research
4.		The Japanese Society for Virology
5.		The Molecular Biology Society of Japan

■ Works

1.	Book	Gene silencing of virus replication by RNA interference. Handbook of Experimental Phamacology RNA Towards Medisine pp.151-171 (Collaboration) 2006/03
2.	Book	Gene silencing of virus replication by RNA interference. Handbook of experimental pharmacology 173,pp.151-171 (Collaboration) 2006
3.	Book	Suppression of HIV-1 replication by siRNA. RNAi Therapeutics pp.43-53 (Single) 2006
4.	Book	Antiviral activity of circular dumbbell RNA/DNA chimeras with closed loop structures in cultured cells. Recent Res. Devel. Nucleosides & Nucleoties pp.17-31 (Collaboration) 2003/01
5.	Book	Antisense oligonucleotide based therapy for influenza Recent Advances in Influenza Virus Research pp.99-118 (Collaboration) 2002/06
6.	Article	Synthesis of 6,6'-Bis(O-4-arylethynylbenzoyl)-α,α-Trehaloses and Their Utilization as Fluorescent Probes for Cellular Imaging European Journal of Organic Chemistry 26,pp.3444-3453 (Collaboration) 2018/07
7.	Article	2-aminophenoxazine-3-one prevents pulmonary metastasis of mouse B16 melanoma cells in mice. Journal of pharmacological sciences 114(1),pp.63-68 (Collaboration) 2010/09
8.	Article	RNA interference targeted to the conserved dimerization initiation site (DIS) of HIV-1 restricts virus escape mutation. Journal of Biochemistry 146(4),pp.481-489 (Collaboration) 2009/10
9.	Article	Inhibition of HIV-1 replication by long-term treatment with a chimeric RNA containing shRNA and TAR decoy RNA. Antiviral research 83(2),pp.156-164 (Collaboration) 2009/08
10.	Article	Anticancer Effects of Phenoxazine Derivatives Revealed by Inhibition of Cell Growth and Viability, Disregulation of Cell Cycle, and Apoptosis Induction in HTLV-1-Positive Leukemia Cells. Journal of Pharmacological Sciences 110(1),pp.87-97 (Collaboration) 2009/05
11.	Article	Induction of natural killer cell-dependent antitumor immunity by the Autographa californica multiple nuclear polyhedrosis virus. Molecular therapy : the journal of the American Society of Gene Therapy 16(2),pp.261-268 (Collaboration) 2008/02
12.	Article	Short-hairpin RNAs synthesized by T7 phage polymerase do not induce interferon. Nucleic acids research 36(3),pp.e18 (Collaboration) 2008/01
13.	Article	Lack of interferon (IFN) response to T7 Transcribed pppG (n)(n = 2,3)-shRNA. Nucleosides, nucleotides & nucleic acids 26(6-7),pp.805-808 (Collaboration) 2007/06
14.	Article	Suppression of hepatitis C virus core protein by short hairpin RNA expression vectors in the core protein expression Huh-7 cells. Nucleosides, nucleotides & nucleic acids 26(6-7),pp.815-820 (Collaboration) 2007/06
15.	Article	Autonomous proliferation of HTLV-CD4+ T cell clones derived from human T cell leukemia virus type I (HTLV-I)-associated myelopathy patients. Microbiology and immunology 51(2),pp.235-242 (Collaboration) 2007
16.	Article	Expression of shRNA using intron splicing. Nucleic acids symposium series 51,pp.409-410 (Collaboration) 2007
17.	Article	2-aminophenoxazine-3-one suppresses the growth of mouse malignant melanoma B16 cells transplanted into C57BL/6Cr Slc mice. Biological & pharmaceutical bulletin 29(11),pp.2197-2201 (Collaboration) 2006/11
18.	Article	Inhibition of HIV-1 replication by vesicular stomatitis virus envelope glycoprotein pseudotyped baculovirus vector-transduced ribozyme in mammalian cells. Biochemical and biophysical research communications 349(4),pp.1220-1227 (Collaboration) 2006/11
19.	Article	Characterization of baculovirus Autographa californica multiple nuclear polyhedrosis virus infection in mammalian cells. Biochemical and biophysical research communications 343(2),pp.378-384 (Collaboration) 2006/05
20.	Article	Inhibition of hepatitis C virus RNA replication by short hairpin RNA synthesized by T7 RNA polymerase in hepatitis C virus subgenomic replicons. Biochemical and biophysical research communications 343(3),pp.988-994 (Collaboration) 2006/05
21.	Article	HIV gene therapy using RNA virus systems. Nucleic acids symposium series 50,pp.79-80 (Collaboration) 2006
22.	Article	Inhibition of hcv replication in HCV replicon by shRNAs. Nucleosides, nucleotides & nucleic acids 25(7),pp.801-805 (Collaboration) 2006
23.	Article	Silencing of HIV-1 gene expression by siRNAs in transduced cells. Nucleosides, nucleotides & nucleic acids 25(7),pp.795-799 (Collaboration) 2006
24.	Article	Silencing of HIV-1 gene expression by two types of siRNA expression systems. Antiviral chemistry & chemotherapy 17(5),pp.241-249 (Collaboration) 2006
25.	Article	Suppression of HIV-1 replication by a combination of endonucleolytic ribozymes (RNase P and tRNnase ZL). Nucleosides, nucleotides & nucleic acids 25(4-6),pp.427-37 (Collaboration) 2006
26.	Article	Resistance to influenza A virus infection by antigen-conjugated CpG oligonucleotides, a novel antigen-specific immunomodulator. Biochemical and biophysical research communications 329(1),pp.230-236 (Collaboration) 2005/04
27.	Article	Anti-tumor effect of intravenous TNFalpha gene delivery naked plasmid DNA using a hydrodynamics-based procedure. Nucleosides, nucleotides & nucleic acids 24(5-7),pp.647-650 (Collaboration) 2005
28.	Article	Lentiviral-mediated delivery of combined HIV-1 decoy TAR and Vif siRNA as a single RNA molecule that cleaves to inhibit HIV-1 in transduced cells. Nucleosides, nucleotides & nucleic acids 24(5-7),pp.431-434 (Collaboration) 2005
29.	Article	Suppression of HCV RNA replication by baculovirus-mediated shRNA expression. Nucleic acids symposium series 49,pp.339-340 (Collaboration) 2005
30.	Article	Suppression of human immunodeficiency virus type 1 (HIV-1) replication by an HIV-1-dependent double locked vector with the Cre/loxP system. Nucleosides, nucleotides & nucleic acids 24(10-12),pp.1907-1917 (Collaboration) 2005
31.	Article	The middle to 3' end of the HIV-1 vif gene sequence is important for vif biological activity and could be used for antisense oligonucleotide targets. Nucleosides, nucleotides & nucleic acids 24(10-12),pp.1745-1761 (Collaboration) 2005
32.	Article	Inhibition of HIV-1 expression through the action of hammerhead ribozymes driven by tRNA promoter. Medicine and Biology 148(12),pp.19-24 (Collaboration) 2004/12
33.	Article	Effective inhibition of HIV-1 replication in cultured cells by external guide sequences and ribonuclease P. Bioorganic & medicinal chemistry letters 14(19),pp.4941-4944 (Collaboration) 2004/10
34.	Article	Anti-tumor effects of naked plasmid DNA using a hydrodynamics-based procedure. Nucleic acids symposium series 48,pp.239-240 (Collaboration) 2004
35.	Article	RNAi expression mediated inhibition of HCV replication. Nucleic acids symposium series 48,pp.307-308 (Collaboration) 2004
36.	Article	Specific HIV-1 env gene silencing by small interfering RNAs in human peripheral blood mononuclear cells. Gene therapy 10(24),pp.2046-2050 (Collaboration) 2003/11
37.	Article	Baculovirus induces an innate immune response and confers protection from lethal influenza virus infection in mice. Journal of immunology 171(3),pp.1133-1139 (Collaboration) 2003/08
38.	Article	A duodenally absorbable CXC chemokine receptor 4 antagonist, KRH-1636, exhibits a potent and selective anti-HIV-1 activity. Proceedings of the National Academy of Sciences of the United States of America 100(7),pp.4185-4190 (Collaboration) 2003/04
39.	Article	A novel single-stranded DNA enzyme expression system using HIV-1 reverse transcriptase. Biochemical and biophysical research communications 301(2),pp.535-539 (Collaboration) 2003/02
40.	Article	Prevention of HIV-1 infection in human peripheral blood mononuclear cells by specific RNA interference. Nucleic acids research 30(22),pp.4830-4835 (Collaboration) 2002/11
41.	Article	Inhibition of HIV-1 replication by an HIV-1 dependent ribozyme expression vector with the Cre/loxP (ON/OFF) system. Antiviral chemistry & chemotherapy 13(5),pp.273-281 (Collaboration) 2002/09
42.	Article	Inhibition of human immunodeficiency virus type 1 activity in vitro by a new self-stabilized oligonucleotide with guanosine-thymidine quadruplex motifs. Journal of virology 76(6),pp.3015-3022 (Collaboration) 2002/03
43.	Article	RNA cleavage by a mammalian tRNA 3'processing endoribonuclease (3'tRNase) reduces HIV-1 expression. Nucleic acids research. Supplement 2,pp.297-298 (Collaboration) 2002
44.	Article	Anti-HIV-1 activity of an antisense phosphorothioate oligonucleotide bearing imidazole and primary amine groups. Bioorganic & medicinal chemistry letters 9(8),pp.2165-2169 (Collaboration) 2001/08
45.	Article	A new class of anti-HIV-1 oligonucleotide targeted to the polypurine tract of viral RNA. Nucleosides, nucleotides & nucleic acids 40(4-7),pp.715-718 (Collaboration) 2001/04
46.	Article	Antisense therapy of influenza. European journal of pharmaceutical sciences : official journal of the European Federation for Pharma 13(1),pp.61-69 (Collaboration) 2001/04
47.	Article	Effective suppression of HIV-1 gene expression by a mammalian tRNA 3' processing endoribonuclease and external guide sequence oligozymes. Nucleosides, nucleotides & nucleic acids 20(4-7),pp.719-722 (Collaboration) 2001/04
48.	Article	Inhibition of HIV-1 replication by the Cre-loxP hammerhead ribozyme. Nucleosides, nucleotides & nucleic acids 20(4-7),pp.723-726 (Collaboration) 2001/04
49.	Article	Effective inhibition of HIV-1 replication in cultured cells by external guide sequences and ribonuclease. Nucleic acids research. Supplement 1,pp.213-214 (Collaboration) 2001
50.	Article	Inhibition of HIV-1 replication by 5'LTR decoy RNA. Nucleic acids research. Supplement (2001) 1,pp.141-142 (Collaboration) 2001
51.	Article	Reverse transcriptional mutagenesis induced by ribonucleoside triphosphate analogue, PTP and its availability for anti-HIV-1 therapy. Nucleic acids research. Supplement 1,pp.255-256 (Collaboration) 2001
52.	Article	Specific inhibition of HIV-1 gene expression by double-stranded RNA. Nucleic acids research. Supplement 1,pp.219-220 (Collaboration) 2001
53.	Article	Inhibitory effects of an antisense oligonucleotide in an experimentally infected mouse model of influenza A virus. Biochemical and biophysical research communications 279(1),pp.158-161 (Collaboration) 2000/12
54.	Article	Anti-HIV-1 activity by a triple-helix forming oligonucleotides targeted to polypurine tract on viral RNA. Nucleosides, nucleotides & nucleic acids 10(10-12),pp.1721-1734 (Collaboration) 2000/10
55.	Article	Antisense phosphorothioate oligonucleotides targeted to the human chemokine receptor CXCR4. Nucleosides, nucleotides & nucleic acids 19(10-12),pp.1709-1719 (Collaboration) 2000/10
56.	Article	Inhibition of HIV-1 replication by a new type of circular dumbbell RNA/DNA chimeric oligonucleotides. Biochemical and biophysical research communications 270(3),pp.953-960 (Collaboration) 2000/04
57.	Article	Inhibition of human telomerase activity by antisense phosphorothioate oligonucleotides encapsulated with the transfection reagent, FuGENE6, in HeLa cells. Antisense & nucleic acid drug development 10(2),pp.87-96 (Collaboration) 2000/04
58.	Article	Down regulation of human immunodeficiency virus type-1 (HIV-1) expression by Vif antisense RNA expression vectors in transfected cells. Nucleic acids research. Supplement 2,pp.123-124 (Collaboration) 2000
59.	Article	Effective suppression of HIV-1 gene expression by a mammalian tRNA 3' processing endoribonuclease and external guide sequence oligozymes. Nucleic acids symposium series 44,pp.207-208 (Collaboration) 2000
60.	Article	Properties of quadruplex oligonucleotides with anti-HIV-1 activity. Nucleic acids symposium series 44,pp.181-182 (Collaboration) 2000
61.	Article	Acquisition of HIV type 1 resistance by beta-chemokine-producing CD4+ T cells. AIDS research and human retroviruses 15(16),pp.1453-1460 (Collaboration) 1999/11
62.	Article	Sequence-specific inhibition of a transcription factor by circular dumbbell DNA oligonucleotides. FEBS letters 461(3),pp.136-140 (Collaboration) 1999/11
63.	Article	Inhibition of HIV-1 replication by a two-strand system (FTFOs) targeted to the polypurine tract. FEBS letters 456(1),pp.186-190 (Collaboration) 1999/07
64.	Article	Specific inhibition of human telomerase activity by transfection reagent, FuGENE6-antisense phosphorothioate oligonucleotide complex in HeLa cells. FEBS letters 454(3),pp.312-316 (Collaboration) 1999/07
65.	Article	Antisense oligonucleotides directed against the viral RNA polymerase gene enhance survival of mice infected with influenza A. Nature biotechnology 17(6),pp.583-587 (Collaboration) 1999/06
66.	Article	Development of an HIV-1-dependent expression vector with the Cre/loxP system. Nucleic acids symposium series 42,pp.295-296 (Collaboration) 1999
67.	Article	Phosphorothioate G3T4G3 motifs inhibits the early stage of HIV-1 infection. Nucleic acids symposium series 42,pp.227-228 (Collaboration) 1999
68.	Article	Properties of circular dumbbell RNA/DNA chimeric oligonucleotides containing antisense phosphodiester oligonucleotides. Nucleic acids symposium series 42,pp.225-226 (Collaboration) 1999
69.	Article	Inhibition of human T-cell leukemia virus type 1 replication by antisense env oligodeoxynucleotide. Biochemical and biophysical research communications 243(1),pp.109-112 (Collaboration) 1998/02
70.	Article	Inhibition of syncytium formation by antisense oligonucleotide phosphorothioates complementary to tax mRNA of human T-cell leukemia virus type 1 (HTLV-1). Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 11(3),pp.42-44 (Collaboration) 1997/04
71.	Article	Long-term, high dose interferon-alpha treatment in HTLV-I-associated myelopathy/tropical spastic paraparesis: a combined clinical, virological and immunological study. Journal of the neurological sciences 147(2),pp.135-144 (Collaboration) 1997/04
72.	Article	Induction of antibody responses that neutralize human T-cell leukemia virus type I infection in vitro and in vivo by peptide immunization. Journal of virology 68(10),pp.6323-6331 (Collaboration) 1994/10
73.	Article	Synergistic inhibition of human immunodeficiencey virus type 1 (HIV-1) replication in vitro by sulphated paramylon and 3'-azido-2',3'-dideoxythymidine (AZT). Letters in Applied Microbiology 18,pp.24-26 (Collaboration) 1994
74.	Article	Anti-HIV (human immunodeficiency virus) activity of sulfated paramylon. Antiviral research 21,pp.1-14 (Collaboration) 1993
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